Cytocell Aquarius Range

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Aquarius probes are directly labelled liquid probes provided in hybridisation solution. The probes are accompanied by DAPI counterstain to provide a complete fluorescence in situ hybridisation kit.

Aquarius* Overview

The Aquarius range consists of directly labelled FISH probes for constitutional cytogenetic and oncology (both pathology and haematology) applications.

The probe mixtures are designed for use on interphase nuclei and metaphase chromosomes from cultured peripheral blood cells or cultured bone marrow samples. There are a wide range of probes in the Aquarius range targeting common FISH signals like breakapart, deletion, translocation, dual fusion, or amplification catered to the customers’ needs.

*All Probes have multiple regulatory status CE-IVD or RUO. Availability is dependent on local country regulatory status. Please contact your local Sysmex Representative for more information.

Benefits of using Aquarius probes

All Aquarius probes are supplied in hybridisation solution and are either ready to use or only require a simple dilution with additional hybridisation solution, which is conveniently supplied in the kit.

The satellite and sub-telomere specific probes are available in a 5-test format whereas the microdeletion syndrome and haematology probes are available in an economical 5 and the standard 10 test formats. Prenatal probes are also available in 30 or 50 test formats.
Our comprehensive range of over 400 Aquarius probes allow ease of visualisation with standard (FITC, Texas Red®, aqua and DAPI) microscope filters.

Haematology

Disease State

MM

Probe*

CKS1B/CDKN2C(P18) Amplification/Deletion
MYC Breakapart
CCND1/11c Amplification
D13S319 Plus Deletion
D13S25/D13S319/RB1 Deletion/ Enumeration
IGH Plus Breakapart
IGH/FGFR3 Plus Translocation, Dual Fusion
IGH/MYEOV Plus Translocation, Dual Fusion
IGH/MAF Plus v2 Translocation, Dual Fusion
IGH/MAFB Plus Translocation, Dual Fusion
IGH/FGFR3 Breakapart/Dual Fusion
IGH/CCND1/MAF Tri-colour, Dual Fusion
IGH/CCND3 Plus Translocation
P53 (TP53) Deletion
15cen /9qhet/5p15.31

Disease State

ALL

Probe*

ABL2 Breakapart
FIP1L1/CHIC2/PDGFRA Deletion
FIP1L1/CHIC2/PDGFRA Tri-colour, Deletion
PDGFRA Breakapart
PDGFRB Breakapart
CSF1R Breakapart
TLX3 Breakapart
TCRB (TRB) Breakapart
TCRG Breakapart
MYC Breakapart
P16 (CDKN2A) Deletion
PAX5 Breakapart
JAK2 Breakapart
ABL1 Breakapart
TLX1 Breakapart
TEL/AML1 (ETV6/RUNX1) Translocation
MLLT10-PICALM Dual Fusion
MLL (KMT2A) Breakapart
MLL/AFF1 Translocation
MLL/MLLT1 Translocation, Dual Fusion
MLL/MLLT3 Translocation, Dual Fusion
MLL/MLLT4 Translocation, Dual Fusion
MLL/MLLT10 Dual Fusion
ETV6 Breakapart
TCRAD Breakapart
IGH Plus Breakapart
IGH/CRLF2 Dual Fusion
TCL1 Breakapart
P53 (TP53) Deletion
E2A (TCF3) Breakapart
E2A/PBX1 Translocation
E2A/PBX1/HLF Translocation
AML1 (RUNX1) Breakapart
BCR/ABL Translocation
BCR/ABL Plus Translocation
BCR/ABL1 Fast-FISH
CRLF2 Breakapart

Disease State

AML

Probe*

NPM1/MLF1 Fusion Probe
DEK/NUP214 Dual Fusion
NUP214 Breakapart
NUP98 Breakapart
NUP98/NSD1 Translocation, Dual Fusion
MLL (KMT2A) Breakapart
MLL/MLLT3 Translocation, Dual Fusion
MLL/MLLT3 Breakapart/Dual Fusion
MLLT10-PICALM Dual Fusion
ETV6 breakapart
MNX1/ETV6 Dual Fusion
PML/RARα (RARA) Translocation
FAST PML/RARα (RARA) Translocation
CBFβ/MYH11 Translocation
CBFB Breakapart in Red
CBFA2T3/GLIS2 Dual Fusion
RARα (RARA) Breakapart
P53 (TP53) Deletion
AML1/ETO (RUNX1/RUNX1T1) Translocation
AML1 (RUNX1) Breakapart
BCR/ABL (ABL1) Translocation

Disease State

MDS

Probe*

EVI1 (MECOM) Breakapart Tri-colour
MECOM/RPN1 Dual-colour, Dual Fusion
Del (5q) Deletion
Del(5q) Plus Deletion
NUP214/DEK Dual Fusion
Del (7q) Deletion
Del(7q) Plus
RELN/TES/7cen
D7S486/EGFR/RELN
NUP98 Breakapart
MLL (KMT2A) Breakapart
TEL/AML1 (ETV6/RUNX1) Translocation
ETV6 Breakapart
P53 (TP53) Deletion
MPO/P53 Amplification/Deletion
Del (20q) Deletion

Disease State

CML/MPN

Probe*

FIP1L1/CHIC2/PDGFRA Deletion
FIP1L1/CHIC2/PDGFRA Tri-colour, Deletion
PDGFRB Breakapart
Del (5q) Deletion
Del(5q) Plus Deletion
Del(7q) Plus
Chromosome 8 Satellite
FGFR1 Breakapart/Amplification
JAK2 Breakapart
ETV6 Breakapart
D13S319 Plus Deletion
P53 (TP53) Deletion
Del (20q) Deletion
BCR/ABL Translocation
BCR/ABL Plus Translocation
BCR/ABL1 Fast-FISH

Disease State

CLL

Probe*

MYB Deletion
ATM Deletion
CCND1 Breakapart
Alpha satellite 12 Plus
D13S319 Plus Deletion
D13S319/13qter/12cen Deletion/Enumeration
D13S25/D13S319/RB1 Deletion/ Enumeration
IGH Plus Breakapart
IGH/BCL2 Plus Translocation
IGH/CCND1 Plus Translocation, Dual Fusion
IGH/BCL3 Dual-colour, Dual Fusion
P53 (TP53) Deletion
P53 (TP53)/ATM Combination
BCL2 Breakapart
CLL PROFILER kit
CLL Screening Panel

Disease State

Lymphoma

Probe*

MYB Deletion
TCRG Breakapart
TCRB (TRB) Breakapart
TLX1 Breakapart
TCRAD Breakapart
TCL1 Breakapart
IGH Plus Breakapart
IGH/BCL2 Plus Translocation
IGH/CCND1 Plus Translocation
IGH/CCND3 Plus Translocation

Haematopathology

Disease State

Lymphoma

Probe*

NTRK1 Breakapart
BCL10 Breakapart
IGK Breakapart
ALK Breakapart
FOXP1
BCL6
TP63 Breakapart
DUSP22/IRF4 Breakapart
BRAF Breakapart
MYC Breakapart
MYC/BCL6 Translocation, Dual Fusion
IGH/cMYC (MYC) Plus Translocation
IGK/MYC Translocation, Dual Fusion
IGL/MYC Translocation, Dual Fusion
IGK/IGL/MYC Tri-colour, Translocation, Dual Fusion
CD274/PDCD1LG2/9qhet (PDL1/2)
P16 (CDKN2A) Deletion
CCND1 Breakapart
11q23/11q24/11cen Amplification/Deletion Probe
11q23/11q24/11cen Probe
CCND2 Breakapart/12cen in Aqua Probe
IGH Breakapart
IGH/BCL2 Translocation
IGH/CCND1 Translocation
IGH/BCL3 Dual Fusion Probe
P53 (TP53) Deletion
BCL2 Breakapart
MALT1 Breakapart
IGH/MALT1 Translocation, Dual Fusion
API2 (BIRC3)/MALT1 Dual Fusion
IGL Breakapart

Pathology

Disease State

Breast Cancer

Probe*

HER2 Amplification
HER2 Tri-colour Amplification
FGFR1 Breakapart/Amplification
EGFR Amplification
TOP2A Amplification/Deletion
CCND1/11c Amplification
ZNF217 Amplification

Disease State

Non Small Cell Lung Cancer

Probe*

ALK Breakapart
ROS1 Plus Breakapart/Deletion
c-MET Amplification
RET Breakapart
EGFR Amplification
FGFR1 Breakapart/Amplification

Disease State

Sarcoma

Probe*

PAX7 Breakapart
ALK Breakapart
PAX3 Breakapart
PDGFB/COL1A1 Dual Fusion
MYC/8c/PVT1 Amplification
CDK4 Amplification (with red)
ETV6 Breakapart
CHOP (DDIT3) Breakapart
MDM2 Amplification
MDM2/12cen Amplification
MDM2/CDK4/12c
FOXO1 Breakapart
FOXO1/PAX3/PAX7 Tri-colour, Dual Fusion
NTRK3 Breakapart
USP6 Breakapart
FUS Breakapart
SYT (SS18) Breakapart
CIC Breakapart (with red)
NUTM1 Breakapart
ZNF217 Amplification
SMARCB1/ARSA Deletion
EWSR1 Breakapart
FLI1/EWSR1 Translocation, Dual Fusion
EWSR1/ERG Translocation, Dual Fusion
TFE3 Breakapart

Disease State

Brain Tumour

Probe*

1p36/1q25 and 19q13/19p13 Deletion
SRD (CHD5) Deletion
NTRK1 Breakapart
NTRK2 Breakapart
NTRK3 Breakapart
N-MYC (MYCN) Amplification
EGFR Amplification
ROS1 Plus Breakapart
FGFR1 Breakapart/Amplification
BRAF/ KIAA1549 Dual Fusion
C-MET (MET) Amplification
MYC Breakapart
P16 (CDKN2A) Deletion
PTEN/10cen
P53 (TP53) Deletion
RELA Breakapart
YAP1 Breakapart
BCOR Breakapart

Disease State

Neuroblastoma

Probe*

N-MYC (MYCN) Amplification
MPO/P53 Amplification/Deletion
ATM/11cen
SRD (CHD5) Deletion
hTERT Breakapart
ALK Breakapart

Disease State

Prostate Cancer

Probe*

SRD (CHD5) Deletion
TMPRSS2/ERG Deletion/breakapart
ZNF217 Amplification
PTEN/10cen
ERG Breakapart

Disease State

Ovarian Cancer

Probe*

c-MET Amplification
ROS1 Plus Breakapart/Deletion
SRD (CHD5) Deletion
TOP2A Amplification/Deletion
ZNF217 Amplification

Disease State

Digestive

Probe*

c-MET Amplification
CCND1 Breakapart
EGFR Amplification
MDM2 Amplification
ROS1 Breakapart
SRD (CHD5) Deletion

Disease State

Pan Cancer

Probe*

NTRK1 Breakapart
NTRK2 Breakapart
NTRK3 Breakapart
ETV6/NTRK3 Dual-colour, Dual Fusion

Constitutional

Disease State

Potsnatal / Neurodevelopmental Disorders

Probe*

Monosomy 1 p36
Wolf-Hirschhorn
Cri-Du-Chat/SOTOS Combination
Saethre-Chotzen/Williams-Beuren Combination
Williams-Beuren
Langer-Giedion
DiGeorge II (10p14)
Angelman (UBE3A/D15S10)
Prader Willi / Angelman (SNRPN)
Rubinstein-Taybi
Smith-Magenis (RAI1)/Miller-Dieker Combination
Smith-Magenis (FLll)/Miller-Dieker Combination
Neurofibromatosis Type 1
Alagille (JAG1)
DiGeorge / VCFS TUPLE 1 and 22q13.3 Deletion
DiGeorge / VCFS N25 and 22q13.3 Deletion
DiGeorge TBX1 and 22q13.3 Deletion
CHARGE
Kallmann (KAL1)/STS Combination
XIST
SHOX
SRY

Disease State

Prenatal / Neonatal Trisomy Screening

Probe*

FAST FISH Enumeration Kit (13,21 & X,Y,18)
FAST FISH X, Y and 18 Enumeration Kit
FAST FISH 13 and 21 Enumeration Kit
FISH Enumeration Probe Kit (13,21 & X,Y,18)
FISH X, Y and 18 Enumeration Kit
FISH 13 and 21 Enumeration Kit
FISH Enumeration kit 18
FISH Enumeration 13,18,21

Disease State

Potsnatal / Sex Chromosome Abnormalities

Probe*

X,Y Satellite Enumeration (G/R)
XIST
SHOX
Kallmann (KAL1)/STS Combination
SRY

Disease State

Potsnatal / Mosaiciam Screening

Probe*

Whole Range Satellite Enumeration (G/R)

Disease State

Recurrent miscarrage screening / Infertility

Probe*

Whole Range Satellite Enumeration (G/R)
Whole Range Subtelomere Specific (G/R)
TeloMark Kit
SRY

+ Features & Benefits

Benefits of using Aquarius probes

All Aquarius probes are supplied in hybridisation solution and are either ready to use or only require a simple dilution with additional hybridisation solution, which is conveniently supplied in the kit.

The satellite and sub-telomere specific probes are available in a 5-test format whereas the microdeletion syndrome and haematology probes are available in an economical 5 and the standard 10 test formats. Prenatal probes are also available in 30 or 50 test formats.
Our comprehensive range of over 400 Aquarius probes allow ease of visualisation with standard (FITC, Texas Red®, aqua and DAPI) microscope filters.

+ Disease State Probes
Haematology

Disease State

MM

Probe*

CKS1B/CDKN2C(P18) Amplification/Deletion
MYC Breakapart
CCND1/11c Amplification
D13S319 Plus Deletion
D13S25/D13S319/RB1 Deletion/ Enumeration
IGH Plus Breakapart
IGH/FGFR3 Plus Translocation, Dual Fusion
IGH/MYEOV Plus Translocation, Dual Fusion
IGH/MAF Plus v2 Translocation, Dual Fusion
IGH/MAFB Plus Translocation, Dual Fusion
IGH/FGFR3 Breakapart/Dual Fusion
IGH/CCND1/MAF Tri-colour, Dual Fusion
IGH/CCND3 Plus Translocation
P53 (TP53) Deletion
15cen /9qhet/5p15.31

Disease State

ALL

Probe*

ABL2 Breakapart
FIP1L1/CHIC2/PDGFRA Deletion
FIP1L1/CHIC2/PDGFRA Tri-colour, Deletion
PDGFRA Breakapart
PDGFRB Breakapart
CSF1R Breakapart
TLX3 Breakapart
TCRB (TRB) Breakapart
TCRG Breakapart
MYC Breakapart
P16 (CDKN2A) Deletion
PAX5 Breakapart
JAK2 Breakapart
ABL1 Breakapart
TLX1 Breakapart
TEL/AML1 (ETV6/RUNX1) Translocation
MLLT10-PICALM Dual Fusion
MLL (KMT2A) Breakapart
MLL/AFF1 Translocation
MLL/MLLT1 Translocation, Dual Fusion
MLL/MLLT3 Translocation, Dual Fusion
MLL/MLLT4 Translocation, Dual Fusion
MLL/MLLT10 Dual Fusion
ETV6 Breakapart
TCRAD Breakapart
IGH Plus Breakapart
IGH/CRLF2 Dual Fusion
TCL1 Breakapart
P53 (TP53) Deletion
E2A (TCF3) Breakapart
E2A/PBX1 Translocation
E2A/PBX1/HLF Translocation
AML1 (RUNX1) Breakapart
BCR/ABL Translocation
BCR/ABL Plus Translocation
BCR/ABL1 Fast-FISH
CRLF2 Breakapart

Disease State

AML

Probe*

NPM1/MLF1 Fusion Probe
DEK/NUP214 Dual Fusion
NUP214 Breakapart
NUP98 Breakapart
NUP98/NSD1 Translocation, Dual Fusion
MLL (KMT2A) Breakapart
MLL/MLLT3 Translocation, Dual Fusion
MLL/MLLT3 Breakapart/Dual Fusion
MLLT10-PICALM Dual Fusion
ETV6 breakapart
MNX1/ETV6 Dual Fusion
PML/RARα (RARA) Translocation
FAST PML/RARα (RARA) Translocation
CBFβ/MYH11 Translocation
CBFB Breakapart in Red
CBFA2T3/GLIS2 Dual Fusion
RARα (RARA) Breakapart
P53 (TP53) Deletion
AML1/ETO (RUNX1/RUNX1T1) Translocation
AML1 (RUNX1) Breakapart
BCR/ABL (ABL1) Translocation

Disease State

MDS

Probe*

EVI1 (MECOM) Breakapart Tri-colour
MECOM/RPN1 Dual-colour, Dual Fusion
Del (5q) Deletion
Del(5q) Plus Deletion
NUP214/DEK Dual Fusion
Del (7q) Deletion
Del(7q) Plus
RELN/TES/7cen
D7S486/EGFR/RELN
NUP98 Breakapart
MLL (KMT2A) Breakapart
TEL/AML1 (ETV6/RUNX1) Translocation
ETV6 Breakapart
P53 (TP53) Deletion
MPO/P53 Amplification/Deletion
Del (20q) Deletion

Disease State

CML/MPN

Probe*

FIP1L1/CHIC2/PDGFRA Deletion
FIP1L1/CHIC2/PDGFRA Tri-colour, Deletion
PDGFRB Breakapart
Del (5q) Deletion
Del(5q) Plus Deletion
Del(7q) Plus
Chromosome 8 Satellite
FGFR1 Breakapart/Amplification
JAK2 Breakapart
ETV6 Breakapart
D13S319 Plus Deletion
P53 (TP53) Deletion
Del (20q) Deletion
BCR/ABL Translocation
BCR/ABL Plus Translocation
BCR/ABL1 Fast-FISH

Disease State

CLL

Probe*

MYB Deletion
ATM Deletion
CCND1 Breakapart
Alpha satellite 12 Plus
D13S319 Plus Deletion
D13S319/13qter/12cen Deletion/Enumeration
D13S25/D13S319/RB1 Deletion/ Enumeration
IGH Plus Breakapart
IGH/BCL2 Plus Translocation
IGH/CCND1 Plus Translocation, Dual Fusion
IGH/BCL3 Dual-colour, Dual Fusion
P53 (TP53) Deletion
P53 (TP53)/ATM Combination
BCL2 Breakapart
CLL PROFILER kit
CLL Screening Panel

Disease State

Lymphoma

Probe*

MYB Deletion
TCRG Breakapart
TCRB (TRB) Breakapart
TLX1 Breakapart
TCRAD Breakapart
TCL1 Breakapart
IGH Plus Breakapart
IGH/BCL2 Plus Translocation
IGH/CCND1 Plus Translocation
IGH/CCND3 Plus Translocation

Haematopathology

Disease State

Lymphoma

Probe*

NTRK1 Breakapart
BCL10 Breakapart
IGK Breakapart
ALK Breakapart
FOXP1
BCL6
TP63 Breakapart
DUSP22/IRF4 Breakapart
BRAF Breakapart
MYC Breakapart
MYC/BCL6 Translocation, Dual Fusion
IGH/cMYC (MYC) Plus Translocation
IGK/MYC Translocation, Dual Fusion
IGL/MYC Translocation, Dual Fusion
IGK/IGL/MYC Tri-colour, Translocation, Dual Fusion
CD274/PDCD1LG2/9qhet (PDL1/2)
P16 (CDKN2A) Deletion
CCND1 Breakapart
11q23/11q24/11cen Amplification/Deletion Probe
11q23/11q24/11cen Probe
CCND2 Breakapart/12cen in Aqua Probe
IGH Breakapart
IGH/BCL2 Translocation
IGH/CCND1 Translocation
IGH/BCL3 Dual Fusion Probe
P53 (TP53) Deletion
BCL2 Breakapart
MALT1 Breakapart
IGH/MALT1 Translocation, Dual Fusion
API2 (BIRC3)/MALT1 Dual Fusion
IGL Breakapart

Pathology

Disease State

Breast Cancer

Probe*

HER2 Amplification
HER2 Tri-colour Amplification
FGFR1 Breakapart/Amplification
EGFR Amplification
TOP2A Amplification/Deletion
CCND1/11c Amplification
ZNF217 Amplification

Disease State

Non Small Cell Lung Cancer

Probe*

ALK Breakapart
ROS1 Plus Breakapart/Deletion
c-MET Amplification
RET Breakapart
EGFR Amplification
FGFR1 Breakapart/Amplification

Disease State

Sarcoma

Probe*

PAX7 Breakapart
ALK Breakapart
PAX3 Breakapart
PDGFB/COL1A1 Dual Fusion
MYC/8c/PVT1 Amplification
CDK4 Amplification (with red)
ETV6 Breakapart
CHOP (DDIT3) Breakapart
MDM2 Amplification
MDM2/12cen Amplification
MDM2/CDK4/12c
FOXO1 Breakapart
FOXO1/PAX3/PAX7 Tri-colour, Dual Fusion
NTRK3 Breakapart
USP6 Breakapart
FUS Breakapart
SYT (SS18) Breakapart
CIC Breakapart (with red)
NUTM1 Breakapart
ZNF217 Amplification
SMARCB1/ARSA Deletion
EWSR1 Breakapart
FLI1/EWSR1 Translocation, Dual Fusion
EWSR1/ERG Translocation, Dual Fusion
TFE3 Breakapart

Disease State

Brain Tumour

Probe*

1p36/1q25 and 19q13/19p13 Deletion
SRD (CHD5) Deletion
NTRK1 Breakapart
NTRK2 Breakapart
NTRK3 Breakapart
N-MYC (MYCN) Amplification
EGFR Amplification
ROS1 Plus Breakapart
FGFR1 Breakapart/Amplification
BRAF/ KIAA1549 Dual Fusion
C-MET (MET) Amplification
MYC Breakapart
P16 (CDKN2A) Deletion
PTEN/10cen
P53 (TP53) Deletion
RELA Breakapart
YAP1 Breakapart
BCOR Breakapart

Disease State

Neuroblastoma

Probe*

N-MYC (MYCN) Amplification
MPO/P53 Amplification/Deletion
ATM/11cen
SRD (CHD5) Deletion
hTERT Breakapart
ALK Breakapart

Disease State

Prostate Cancer

Probe*

SRD (CHD5) Deletion
TMPRSS2/ERG Deletion/breakapart
ZNF217 Amplification
PTEN/10cen
ERG Breakapart

Disease State

Ovarian Cancer

Probe*

c-MET Amplification
ROS1 Plus Breakapart/Deletion
SRD (CHD5) Deletion
TOP2A Amplification/Deletion
ZNF217 Amplification

Disease State

Digestive

Probe*

c-MET Amplification
CCND1 Breakapart
EGFR Amplification
MDM2 Amplification
ROS1 Breakapart
SRD (CHD5) Deletion

Disease State

Pan Cancer

Probe*

NTRK1 Breakapart
NTRK2 Breakapart
NTRK3 Breakapart
ETV6/NTRK3 Dual-colour, Dual Fusion

Constitutional

Disease State

Potsnatal / Neurodevelopmental Disorders

Probe*

Monosomy 1 p36
Wolf-Hirschhorn
Cri-Du-Chat/SOTOS Combination
Saethre-Chotzen/Williams-Beuren Combination
Williams-Beuren
Langer-Giedion
DiGeorge II (10p14)
Angelman (UBE3A/D15S10)
Prader Willi / Angelman (SNRPN)
Rubinstein-Taybi
Smith-Magenis (RAI1)/Miller-Dieker Combination
Smith-Magenis (FLll)/Miller-Dieker Combination
Neurofibromatosis Type 1
Alagille (JAG1)
DiGeorge / VCFS TUPLE 1 and 22q13.3 Deletion
DiGeorge / VCFS N25 and 22q13.3 Deletion
DiGeorge TBX1 and 22q13.3 Deletion
CHARGE
Kallmann (KAL1)/STS Combination
XIST
SHOX
SRY

Disease State

Prenatal / Neonatal Trisomy Screening

Probe*

FAST FISH Enumeration Kit (13,21 & X,Y,18)
FAST FISH X, Y and 18 Enumeration Kit
FAST FISH 13 and 21 Enumeration Kit
FISH Enumeration Probe Kit (13,21 & X,Y,18)
FISH X, Y and 18 Enumeration Kit
FISH 13 and 21 Enumeration Kit
FISH Enumeration kit 18
FISH Enumeration 13,18,21

Disease State

Potsnatal / Sex Chromosome Abnormalities

Probe*

X,Y Satellite Enumeration (G/R)
XIST
SHOX
Kallmann (KAL1)/STS Combination
SRY

Disease State

Potsnatal / Mosaiciam Screening

Probe*

Whole Range Satellite Enumeration (G/R)

Disease State

Recurrent miscarrage screening / Infertility

Probe*

Whole Range Satellite Enumeration (G/R)
Whole Range Subtelomere Specific (G/R)
TeloMark Kit
SRY

+ More information